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What is MDR??
Multidrug Sensitivity in Dogs *
Drug sensitivities result from a mutation in the multi-drug resistance gene (MDR1). This gene encodes a protein, P-glycoprotein that is responsible for pumping many drugs and other toxins out of the brain. Dogs with the mutant gene cannot pump some drugs out of the brain as a normal dog would, which may result in abnormal neurologic signs. The result may be an illness requiring an extended hospital stay - or even death.
Some dog breeds are more sensitive to certain drugs than other breeds. Collies and related breeds, for instance, can have adverse reactions to drugs such as ivermectin and loperamide (Imodium). At Washington State University's College of Veterinary Medicine you can get your dog tested for drug sensitivity and keep up with the latest research.
Veterinary Clinical Pharmacology Laboratory PO Box 609 , Washington State University, Pullman WA 99163-0609, 509-335-3745, Contact Us Safety Links
* Above article assembled from information at the VCPL website